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Meili Medicine


Brittany Ayers
Brittany AyersPublished on August 20, 2022

The liver breaks down, synthesizes, & metabolizes compounds, including toxins to be excreted through urine or bowels. The liver also processes pharmaceuticals, nutrients, or hormones to be converted into a usable form. This is a 3 phase process.

Phase 1 - Biotransformation

Phase 2 - Detoxification - Conjugation

Phase 3 - Excretion

We discuss each one of these phases in more detail in the Better Liver program.

Isothiocyanates are a family of organic compounds found in cruciferous vegetables.

Sulforaphane is an isothiocyanate that activates various pathways which promote health.

Notable Sulforaphane Functions:

  • Activates Phase 2 Conjugation

  • Deactivates Phase 1 - biotransformation enzymes → deactivates carcinogens

  • Augments expression of NQ01 gene → increases glutathione (master antioxidant)

  • Activates NRF2 Pathway → activates a protein that regulates antioxidants

Sulforaphane is an important compound that deactivates carcinogens, drives healthy glutathione levels, and regulates antioxidants. Sulforaphane is known as the “most powerful superfood” available.

SO what does this all mean??

  • Decrease risk of cancer

  • Increase detoxification pathways

  • Decrease cardiovascular disease

  • Increase antioxidant production

  • Decrease risk of neurodegenerative disease

  • Anti Aging properties

Glucoraphanin is a precursor to sulforaphane.

Glucoraphanin is found in high concentrations in broccoli sprouts.

Myrosinase is an enzyme that breaks down glucoraphanin into sulforaphane. This enzyme is catalyzed through mastication, heat, pH, and pressure. One study found that heating your broccoli sprouts will increase the amount of sulforaphane. When sulforaphane is increased the health benefits of this powerful superfood are increased.

How to increase the bioavailability of sulforaphane in broccoli sprouts by 3x

  1. Heat water to 70*C or 158*F

  2. Thoroughly soak sprouts in heated water.

  3. Soak for 10 minutes

  4. Drain water & enjoy. Sprouts can be stored in the refrigerator for up to a week.

The optimal amount of broccoli sprouts to achieve wellness is about 60g a day. It can be blended in a smoothie and added to salads or soups.

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